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Clinical trial data suggested that zoloft may increase phenytoin concentrations see drug interactions .

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Patients in Study PMDD-1 met DSM-III-R criteria for Late Luteal Phase Dysphoric DisorderLLPDDthe clinical entity referred to as PMDD in DSM-IVPatients in Study PMDD-2 met DSM-IV criteria for PMDDStudy PMDD-1 utilized continuous daily dosing throughout the studywhile Study PMDD-2 utilized luteal phase dosingintermittent dosingfor the 2 weeks prior to the onset of mensesThe mean duration of PMDD symptoms was approximately 10.5 years in both studiesPatients taking oral contraceptives were excluded from these trialsthereforethe efficacy of ZOLOFT in combination with oral contraceptives for the treatment of PMDD is unknown.

SNRIs and SSRIsincluding ZOLOFThave been associated with cases of clinically significant hyponatremia in elderly patientswho may be at greater risk for this adverse reactionSee WARNINGS AND PRECAUTIONS

Table 2Risk Differences of the Number of Cases of Suicidal Thoughts or Behaviors in the Pooled Placebo-Controlled Trials of Antidepressants in Pediatric and Adult Patients.

Do not use sertraline if you have used an MAO inhibitor such as furazolidoneFuroxoneisocarboxazidMarplanphenelzineNardilrasagilineAzilectselegilineEldeprylEmsamZelaparor tranylcypromineParnatein the last 14 daysA dangerous drug interaction could occurleading to serious side effectsYou must wait at least 14 days after stopping an MAO inhibitor before you can take sertralineAfter you stop taking sertralineyou must wait at least 14 days before you start taking an MAOI.

Oral solution a clearcolorless solution with a menthol scent containing sertraline hydrochloride equivalent to 20 mg of sertraline per mL and 12alcoholIt is supplied as a 60 mL bottle with an accompanying calibrated dropper that has 25 mg and 50 mg graduation marks.

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children and adolescents for ocd obsessive compulsive disorder, it is recommended that you begin with zoloft 25mg daily in children whose age fall between 6 and 12 years, in those within the age bracket of 13 and 17 should be placed on 50 mg of zoloft daily.