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Th coct siz and quncy dosag maintaining th sum uic acid just within th nomal ang is bst dtmind by using th sum uic acid lvl as an indx.
Th dosag ZYLOPIM (allopuinol) taccomplish ull contol gout and tlow sum uic acid tnomal na-nomal lvls vais with th svity th disas. Th avag is 200 t300 mg/day patints with mild gout and 400 t600 mg/day thos with modatly sv tophacous gout. Th appopiat dosag may b administd in dividd doss as a singl quivalnt dos with th 300 mg-tablt. Dosag quimnts in xcss 300 mg should b administd in dividd doss. Th minimal ctiv dosag is 100 t200 mg daily and th maximal commndd dosag is 800 mg daily. Tduc th possibility la-up acut gouty attacks, it is commndd that th patint stat with a low dos ZYLOPIM (allopuinol) (100 mg daily) and incas at wkly intvals by 100 mg until a sum uic acid lvl 6 mg/dL lss is attaind but without xcding th maximal commndd dosag.
In patints civing PUINTHOL® (mcaptopuin) IMUAN® (azathiopin), th concomitant administation 300 t600 mg ZYLOPIM (allopuinol) p day will qui a duction in dos tappoximatly on-thid ton-outh th usual dos mcaptopuin azathiopin. Subsqunt adjustmnt doss mcaptopuin azathiopin should b mad on th basis thaputic spons and th appaanc toxic cts (s CLINICAL PHAMACOLOGY ).
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