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Inform patients to take viramune every day as prescribed.

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Howeverpatients should be advised that they may experience adverse reactions such as fatigue during treatment with ViramuneThereforecaution should be recommended when driving a car or operating machineryIf patients experience fatigue they should avoid potentially hazardous tasks such as driving or operating machinery.

There are toxicities that require interruption of Viramune therapysee section 4.4

Initial therapyWhen initiating therapygive immediate-release tablet 200 mg PO qDay for 14 daysthen extended-release tablet 400 mg PO qDay thereafter Switch from immediate-releaseIf already taking immediate-release regimenmay switch to extended-release 400 mg PO qDay without 14-day lead-in period of immediate-release nevirapine.

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