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Acute hemolytic anemiaincluding cases resulting in deathhas been reported in patients treated with CRIXIVANOnce a diagnosis is apparentappropriate measures for the treatment of hemolytic anemia should be institutedincluding discontinuation of CRIXIVAN.

Campo REMoreno JNSuarez Get alEfficacy of indinavir-ritonavir-based regimens in HIV-1-infected patients with prior protease inhibitor failuresAIDS2003;17(131933-1939.

A CRIXIVAN dose of 800 mg every 8 hourswith zidovudine 200 mg every 8 hours and lamivudine 150 mg twice a dayhas been studied in 16 HIV-infected pregnant patients at 14 to 28 weeks of gestation at enrollmentstudy PACTG 358Given the substantially lower antepartum exposures observed and the limited data in this patient populationindinavir use is not recommended in HIV-infected pregnant patientssee CLINICAL PHARMACOLOGYPregnant Patients

Indinavir is used in combination with several other anti-HIV drugsusually nukesnucleoside analoguesand sometimes including drugs from other classes such as non-nukesnon-nucleoside reverse transcriptase inhibitorsCombinations such as this are called antiretroviral therapyor ARTFor more information on ARTsee CATIE’s Your Guide to HIV Treatment

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in hiv-infected pediatric patients age 4-15 years , a dosage regimen of indinavir capsules, 500 mg m 2 every 8 hours, produced auc 0-8hr of 38,742 24,098 nm hour n 34 , c max of 17,181 9809 nm n 34 , and trough concentrations of 134 91 nm n 28 .