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Promethazine may cause your skin to become more sensitive to sunlight than normal.

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Since promethazine HCI administered intravenouslyby injectioncan cause severe chemical irritation and damage to tissuesdeep intramuscular injectiona technique administering medication deep into the musclesis the preferred method of injectionPromethazine hydrochloride injections should not be given by intra-arterialwithin an arteryinjectionunder any circumstancesdue to the risk of severe arteriospasmspasm in an arteryand resulting gangrene.

Sedating drugs may cause confusion and over-sedation in the elderlyelderly patients generally should be started on low doses of promethazine hydrochloride tablets and observed closely.

Take this medication by mouth with or without food as directed by your doctorusually 2 to 4 times dailyFor motion sicknessthe first dose of promethazine should be taken 30 to 60 minutes before beginning travelFor allergiesthis medication may be taken once daily at bedtime to avoid being drowsy during the dayWhen used before surgerypromethazine may be taken the night before or just before the procedure and may be continued afterwards as directed.

Blood pressure medication such as guanadrelHylorelguanethidineIsmelinpropranololInderaland others;

The black box warning now clearly reads that promethazine hydrochloride injections should not be used in pediatric patients less than 2 years of age because of the potential for fatal respiratory depressionIt also advises caution should be exercised when administering the drug in the form of an injection to patients 2 and older.

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