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Although clinical studies have shown that CRESTOR alone does not reduce basal plasma cortisol concentration or impair adrenal reservecaution should be exercised if CRESTOR is administered concomitantly with drugs that may decrease the levels or activity of endogenous steroid hormones such as ketoconazolespironolactoneand cimetidine.

It is not known if CRESTOR is safe and effective in people who have Fredrickson Type I and V dyslipidemias.

Your doctor should do blood tests to check your liver before starting treatment and if you have symptoms of liver problems while taking CRESTOR Call your doctor right away if youHave unexplained muscle pain or weaknessespecially with fever Have muscle problems that do not go away even after your doctor told you to stop taking CRESTOR Feel unusually tired Have loss of appetiteupper belly paindark urineor yellowing of skin or eyesThese could be signs of rare but serious side effects Elevated blood sugar levels have been reported with statinsincluding CRESTOR Side effectsThe most common side effects may include headachemuscle achesabdominal painweaknessand nauseaMemory loss and confusion have also been reported with statinsincluding CRESTOR Tell your doctor and pharmacist about other medicines you are taking.

Children and adolescents 7 to 15 years of age with homozygous familial hypercholesterolemia were studied in a 6-week randomizedplacebo-controlledcross-over study with CRESTOR 20 mg once daily followed by 12 weeks of open-label treatmentsee Clinical StudiesIn generalthe safety profile in this trial was consistent with that of the previously established safety profile in adults.

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