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Benzoyl peroxide can be very irritating and may decrease the effectiveness of tretinoin if the two products are applied at the same time.

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Although the exact mode of action of tretinoin is unknowncurrent evidence suggests that topical tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formationAdditionallytretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells causing extrusion of the comedones.

Use tretinoin topical exactly as your doctor has prescribed it for youUsing more medicine or applying it more often than prescribed will not make it work any fasterand may increase side effectsDo not use this medication for longer than your doctor has prescribed.

Laboratory findingsWhen laboratory mice are exposed to artificial sunlightthey often develop skin tumorsThese sunlight-induced tumors may appear more quickly and in greater number if the mouse is also topically treated with the active ingredient in RETIN-AtretinoinIn some studiesunder different conditionshoweverwhen mice treated with tretinoin were exposed to artificial sunlightthe incidence and rate of development of skin tumors was reducedThere is no evidence to date that tretinoin alone will cause the development of skin tumors in either laboratory animals or humansHoweverinvestigations in this area are continuing.

Tretinoin Cream in a 0.025concentrationValid prescription requiredPlease see Prescribing Information.

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