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Prograf should not be used simultaneously with cyclosporine see dosage and administration .

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Nervous system problems are a serious and common side effect of PROGRAFCall your healthcare provider right away if you get any of these symptoms while taking PROGRAFThese could be signs of a serious nervous system problem:

Tacrolimus can make you more likely to get infections or may worsen any current infectionsThereforewash your hands well to prevent the spread of infectionAvoid contact with people who have infections that may spread to otherssuch as chickenpoxmeaslesfluConsult your doctor if you have been exposed to an infection or for more details.

This medication may increase your risk of developing skin cancerLimit your time in the sunAvoid tanning booths and sunlampsUse sunscreen and wear protective clothing when outdoors.

ISMP Canada received a report of a medication incident in which Advagrafan extended-release formulation of tacrolimus for oral administrationwas dispensed to a patient instead of the intended Prografan immediate-release oral formulation of the same drugRecent reports from the United Kingdom 12 and Europe 34 have documented mix-ups between Prograf and Advagraf and have outlined concerns about the outcomes of such incidentsAccording to these warningsmix-ups between Prograf and Advagraf have led to serious harmincluding cases of biopsy-confirmed acute rejection of transplanted organs and toxic effects due to overexposureAlthough this incident occurred in a community pharmacyit is an important alert for hospital pharmacists about the potential for serious patient harm if these drugs are mistakenly interchanged.

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pharmacokinetic data indicate that whole blood concentrations rather than plasma concentrations serve as the more appropriate sampling compartment to describe prograf pharmacokinetics.