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People with a known sensitivity to amlodipine should not take norvasc.

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Titrate dose every 7-14 days on a given dosepeak antihypertensive effect is delayed.

Amlodipine is a calcium channel blockerIt blocks special channels on the surface of cells called calcium channelsthrough which calcium particles normally enterWhen calcium enter the cells in the muscles of blood vessel wallsthis causes contractionBy reducing the flow of calcium into the cellsamlodipine prevents the blood vessel walls from contractingthus lowering the blood pressure for patients with hypertension and helping to make it easier for patients with heart problems to pump blood around the body.

Amlodipine is used with or without other medications to treat high blood pressureLowering high blood pressure helps prevent strokesheart attacksand kidney problemsAmlodipine belongs to a class of drugs known as calcium channel blockersIt works by relaxing blood vessels so blood can flow more easily.

The limited available data based on post-marketing reports with Norvasc use in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriageThere are risks to the mother and fetus associated with poorly controlled hypertension in pregnancysee Clinical ConsiderationsIn animal reproduction studiesthere was no evidence of adverse developmental effects when pregnant rats and rabbits were treated orally with amlodipine maleate during organogenesis at doses approximately 10 and 20-times the maximum recommended human doseMRHDrespectivelyHowever for ratslitter size was significantly decreasedby about 50and the number of intrauterine deaths was significantly increasedabout 5-foldAmlodipine has been shown to prolong both the gestation period and the duration of labor in rats at this dosesee Data

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