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Naltrexone appears to have extra-hepatic sites of drug metabolism and its major metabolite undergoes active tubular secretionsee Metabolism aboveAdequate studies of naltrexone in patients with severe hepatic or renal impairment have not been conductedsee PRECAUTIONSSpecial Risk Patients
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NoteIndividual patientsespecially those with opioid dependencemay respond to lower doses of naloxoneIn some cases0.1 mg IV naloxone has produced a diagnostic response.
During two randomizeddouble-blind placebo-controlled 12-week trials to evaluate the efficacy of REVIA as an adjunctive treatment of alcohol dependencemost patients tolerated REVIA wellIn these studiesa total of 93 patients received REVIA at a dose of 50 mg once dailyFive of these patients discontinued REVIA because of nauseaNo serious adverse events were reported during these two trials.
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