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Information about Methotrexate.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking methotrexate.

Many drugs can interact with methotrexateThis includes prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed hereTell your doctor about all your current medicines and any medicine you start or stop using.

Methotrexate is a strong medicationThe dosage and how often you take this medication are based on your medical condition and response to treatmentThere are many different dosing schedules for this medicationespecially for cancer treatmentTaking this medication the wrong way may cause serious side effectsincluding deathThereforeit is very important that you follow your doctor’s instructions carefullyTake this medication by mouth as directed by your doctor.

Effectiveness of therapy is ordinarily evaluated by 24 hour quantitative analysis of urinary chorionic gonadotropinhCGwhich generally will return to normal or less than 50 intl units/24 hours usually after the third or fourth course and usually followed by a complete resolution of measurable lesions in 4 to 6 weeksOne to two courses of methotrexate after normalization of hCG is usually recommended.

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although methotrexate has been reported to cause chromosomal damage to animal somatic cells and bone marrow cells in humans, these effects are transient and reversible.