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Levetiracetam, also known as keppra, is an anti-seizure medication utilized by veterinarians to treat animals suffering from seizure disorders.

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Potential drug interactions between KEPPRA and other AEDscarbamazepinegabapentinlamotriginephenobarbitalphenytoinprimidone and valproatewere also assessed by evaluating the serum concentrations of levetiracetam and these AEDs during placebo-controlled clinical studiesThese data indicate that levetiracetam does not influence the plasma concentration of other AEDs and that these AEDs do not influence the pharmacokinetics of levetiracetam.

KEPPRA1000 mg twice dailydid not influence the pharmacokinetics and pharmacodynamicsECGof digoxin given as a 0.25 mg dose every dayCoadministration of digoxin did not influence the pharmacokinetics of levetiracetam.

The administration of levetiracetam to patients with renal impairment may require dose adjustmentIn patients with severely impaired hepatic functionassessment of renal function is recommended before dose selectionsee section 4.2

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