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This section provides specific dosing recommendations for patients older than 12 years and patients aged 2 to 12 yearsWithin each of these age-groupsspecific dosing recommendations are provided depending upon concomitant AEDs or other concomitant medicationssee Table 1 for patients older than 12 years and Table 2 for patients aged 2 to 12 yearsA weight-based dosing guide for patients aged 2 to 12 years on concomitant valproate is provided in Table 3.

Medication errors involving LAMICTAL have occurredIn particularthe names LAMICTAL or lamotrigine can be confused with the names of other commonly used medicationsMedication errors may also occur between the different formulations of LAMICTALTo reduce the potential of medication errorswrite and say LAMICTAL clearlyDepictions of the LAMICTAL tabletschewable dispersible tabletsand orally disintegrating tablets can be found in the Medication Guide that accompanies the product to highlight the distinctive markingscolorsand shapes that serve to identify the different presentations of the drug and thus may help reduce the risk of medication errorsTo avoid the medication error of using the wrong drug or formulationpatients should be strongly advised to visually inspect their tablets to verify that they are LAMICTALas well as the correct formulation of LAMICTALeach time they fill their prescription.

In healthy volunteers not receiving any other medications and given single dosesthe plasma concentrations of lamotrigine increased in direct proportion to the dose administered over the range of 50 to 400 mgIn 2 small studiesn7 and 8of patients with epilepsy who were maintained on other AEDsthere also was a linear relationship between dose and lamotrigine plasma concentrations at steady state following doses of 50 to 350 mg twice daily.

Experience in patients with hepatic impairment is limitedBased on a clinical pharmacology study in 24 subjects with mildmoderateand severe liver impairmentsee Use In Specific PopulationsCLINICAL PHARMACOLOGYthe following general recommendations can be madeNo dosage adjustment is needed in patients with mild liver impairmentInitialescalationand maintenance doses should generally be reduced by approximately 25in patients with moderate and severe liver impairment without ascites and 50in patients with severe liver impairment with ascitesEscalation and maintenance doses may be adjusted according to clinical response.

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the effectiveness of lamictal xr as adjunctive therapy in partial-onset seizures, with or without secondary generalization, was established in a 19-week, multicenter, double-blind, placebo-controlled trial in 236 patients aged 13 years and older approximately 93 of patients were aged 16 to 65 years .