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Current non-surgical therapies of kidney stones take 3 different approachesPreventioneither primary or secondary is preferredIndeedevidence exists that supports the prescription of specific dietary measures and/or drugs for this purposeChemolysisdissolutionof existing stones may be possible with uric acid and some cystine stonesNo scientific data supports the feasibility of calcium stone chemolysisto our knowledgeExpulsion therapy to help pass stones that have moved into the ureterbut not stones resident in the kidneyishoweversupported by recent controlled trials6.

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Kidney stones are a global affliction causing a great deal of morbidity and economic loss1 The prevalence of nephrolithiasis increases as societies become industrialized2,3,4 Thereforethe worldwide burden is likely to increase in future yearsA method to prevent kidney stones would be an obvious benefitExisting treatments with evidence that supports their long term efficacy to prevent calcium oxalate kidney stones include dietary and lifestyle changesas well as chronic use of one of three medicationsthiazidespotassium citrateand allopurinolNo new treatments have been established in decadesand these that are available have inherent problems related to patient compliancecosteffectiveness and side effectsThereforea preventive treatment that would be easy to takelow in costsafe and effective would be highly desirable.

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