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We studied the effects of single intravenous doses of furosemide 1, 3, and 10 mg and of normal saline infusion 750 ml on urinary thiamine excretion in 6 volunteers.

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LasixFurosemideis one of the most commonly prescribed medications for the treatment of hypertensionwhich is accompanied by massive swellingThe therapeutic effectiveness of this medication has been confirmed by data reported in clinical trialsIn most casesLasix is used as one of the primary components involved in the complex therapy for essential hypertension.

60Peak plasma drug concentrations are reached 1-2h after oral administrationBecause furosemide is bound extensively to plasma proteinsits delivery to the tubules by filtration is limitedHoweverit is secreted efficiently by the organic acid transport system in the proximal tubule and thereby gains access to its binding sites on the Na-K-2Cl symporters in the luminal plasma membrane of the thick ascending limb.

Lasix overdose results in rapid dehydrationThe BCC decreasesthe volume of circulating bloodand cardiac arrhythmias and/or blockades developBlood pressure also sharply dropsacute renal failure occursand consciousness is disturbed.

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