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Ribavirin and sofosbuvir have been tested in people who are co-infected with HIV and Hep CFor more informationsee the sofosbuvir fact sheet.

PatientsOne hundred and thirty-four patients from 20 to 71 years old with chronic hepatitis C who had previously received one course of conventional IFN3-6 MU tiwplus ribavirin800-1200 mg qdfor at least 24 weeks were considered eligible for this studyAmong these97 patients never achieved undetectable HCV RNA levelsqualitative PCR testingduring the first treatmentnonrespondersgroup Aand 37 patients showed undetectable HCV RNA during the first therapy but became HCV RNA positive after discontinuing medicationrelapsersgroup BAt the baselinethe patients were HCV RNA positivehad elevated ALTdefined as ALT above the upper limit of normaland had a liver biopsy consistent with chronic hepatitis CExclusion criteria were previous course of conventional IFN monotherapyage below 18 yearsHBV or HIV virus infectionplatelet count 3neutrophil count 3 and hemoglobin levels 40 yearsviral load800.000 IU versus800.000 IUhistological statusno cirrhosis vs cirrhosisHCV genotype1 and 4 versus 2 and 3and adherenceadherent versus nonadherentAn exact 95confidence interval from the binomial distribution was determined for each prognostic variable.

Fever Headache Low white blood cell counts Fatigue or tiredness Loss of appetite Redness at the injection site Vomiting 2.

When ribavirin is taken with the following medicationsdrug interactions may occur:

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-sudden deterioration of respiratory function has been associated with initiation of ribavirin 200 mg oral tablet copegus inhalation therapy in infants, careful monitoring of respiratory function during therapy recommended.