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See ContraindicationsDo not start with concomitant linezolid or IV methylene blueif treatment is necessarydiscontinue fluoxetine before startingmonitor for serotonin syndrome for 5 weeks or until 24hrs after last dose of linezolid or IV methylene bluewhichever comes firstDo not start thioridazine within at least 5 weeks of discontinuing fluoxetineConcomitant SSRIsSNRIstryptophannot recommendedIncreased risk of serotonin syndrome with other serotonergic drugsegtriptanstricyclic antidepressantsfentanyllithiumtramadoltryptophanbuspironeamphetaminesStJohn’s Wortor with drugs that impair serotonin metabolismegMAOIslinezolidIV methylene blueMay potentiate protein-bound drugsegwarfarindigoxinand those metabolized by CYP2D6egtricyclicsvinblastineflecainideMay potentiate carbamazepinephenytoinMonitor lithiumphenytoinwarfarintricyclicsCaution with benzodiazepinesegdiazepamalprazolamantipsychoticsegclozapinehaloperidolother CNS drugsantiplateletsIncreased risk of bleeding with NSAIDsaspirinwarfarinand others that affect coagulationHyponatremia with diuretics.

Pulmonary reactionsincluding inflammatory processes of varying histopathology and/or fibrosishave been reported rarelyThese reactions have occurred with dyspnea as the only preceding symptom.

Tell the doctor right away if you notice worsening depression/other psychiatric conditionsunusual behavior changesincluding possible suicidal thoughts/attemptsor other mental/mood changesincluding new/worsening anxietypanic attackstrouble sleepingirritabilityhostile/angry feelingsimpulsive actionssevere restlessnessvery rapid speechBe especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.

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