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Administration of cilostazol with omeprazolean inhibitor of CYP2C19increased the AUC of cilostazol by 22accompanied by a 68increase in the AUC of the dehydro metabolite and a decrease of 36in the AUC of the 4trans hydroxy metaboliteBased on AUCthe overall pharmacological activity increases by 47when co-administered with omeprazoleBased on these datathe recommended dose of cilostazol is 50 mg bid in the presence of omeprazole.

Based on AUCoverall pharmacological activity of cilostazol increases 19when co-administered with diltiazemBased on these datano dose adjustment is necessary.

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