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Evidence from clinical trials documents the efficacy of topiramate in acute mania key concept objective to be familiar with different drugs available for the treatment of bipo- lar disorder and mania lithium is most effective in classic bipolar disorder, which consists of discrete episodes of mania and depression with symptom-free periods between episodes.

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Lithium is used to treat the manic episodes of bipolar disordermanic depressionManic symptoms include hyperactivityrushed speechpoor judgmentreduced need for sleepaggressionand anger.

Materials experts have moved to quell lithium supply fears in the face of a continuing slide in the value of the mineral.

Doses vary widely and are adjusted based on measurements of the levels of lithium in the bloodRecommended blood levels are 0.6-1.2 mEq/LEarly in therapydose adjustments are made as often as every 5 to 7 days to establish the correct doseMost patients require 900-2400 mg daily in 2-4 divided doses depending on the formulation being usedPatients with kidney disease excrete less lithium from the body andthereforerequire lower doses.

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