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LIORESAL INTRATHECALbaclofen injectionis packaged in single use ampules containing 0.05 mg/1 mL50mcg/mL10 mg/20 mL500 mcg/mL10 mg/5 mL2000 mcg/mLor 40 mg/20 mL2000 mcg/mLsupplied as follows:
Hallucinations and seizures have occurred on abrupt withdrawal of LioresalThereforeexcept for serious adverse reactionsthe dose should be reduced slowly when the drug is discontinued.
Baclofen is used to treat muscle spasms caused by certain conditionssuch as multiple sclerosisspinal cord injury/diseaseIt works by helping to relax the muscles.
PEDIATRIC USE Children should be of sufficient body mass to accommodate the implantable pump for chronic infusionPlease consult pump manufacturer’s manual for specific recommendations.
Pharmacokinetics of LIORESAL INTRATHECALThe pharmacokinetics of CSF clearance of LIORESAL INTRATHECAL calculated from intrathecal bolus or continuous infusion studies approximates CSF turnoversuggesting elimination is by bulk-flow removal of CSF.
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