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Etodolac is a member of the pyranocarboxylic acid class of NSAIDsIn vitro data suggest that etodolac is not COX-2 selective in dogs14,34,35 However in vivo data are conflicting with evidence suggesting that platelet thromboxane and gastric prostaglandin PGE 1 were not inhibited by etodolac in dogs at recommended therapeutic doses17 Thusit is difficult to state definitively whether etodolac is COX-1 sparing in vivoEtodolac is approved as an oral formulation for use in managing pain and inflammation associated with canine OAClinicallyetodolac has been shown to improve rear limb function in dogs with chronic OA67-69 Adverse events are primarily seen in the GI tracthoweverkeratoconjunctivitis sicca has also been associated with etodolac administration70-72.

Patricia ATalcott MSDVMPhDDABVTSharon MGwaltney-Brant DVMPhDDABVTDABTin Small Animal ToxicologyThird Edition2013.

DiureticsReduced diuretic effectDiuretics can increase the risk of nephrotoxicity of NSAIDs.

I took one pill and it gave me ringing of the ears next dayA rash and severe stomach indigestion with sharp pains its been two days now miserablewish I never went to the DrI am worse off.

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