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Ondansetron is absorbed from the gastrointestinal tract and undergoes some first-pass metabolismMean bioavailability in healthy subjectsfollowing administration of a single 8-mg tabletis approximately 56

Do not attempt to push ZOFRAN ODT tablets through the foil backingWith dry handsPEEL BACK the foil backing of 1 blister and GENTLY remove the tabletIMMEDIATELY place the ZOFRAN ODT tablet on top of the tongue where it will dissolve in secondsthen swallow with salivaAdministration with liquid is not necessary.

Keep the tablet in its blister pack until you are ready to take the medicineOpen the package and peel back the foil from the tablet blisterDo not push a tablet through the foil or you may damage the tabletUsing dry handsremove the tablet and place it in your mouthIt will begin to dissolve right awayDo not swallow the tablet wholeAllow it to dissolve in your mouth without chewingSwallow several times as the tablet dissolvesIf desiredyou may drink liquid to help swallow the dissolved tablet.

Ondansetron orally disintegrating tablets may contain phenylalanineTell your doctor if you have phenylketonuriaPKU

Carmustineetoposideand cisplatin do not affect the pharmacokinetics of ondansetron.

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