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Budesonide undergoes approximately 85 first-pass metabolism to two inactive metabolites 16-alpha-hydroxyprednisolone 24 and 6-beta-hydroxybudesonide 5 .

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Prednisolone may cause vaccines not to work as wellThereforedo not have any immunizations/vaccinations while using this medication without the consent of your doctorAvoid contact with people who have recently received live vaccinessuch as flu vaccine inhaled through the nose

This summary of a Cochrane review presents what we know from research about the effect of lifestyle modifications in the treatment of people with acute goutThere was one study included in this reviewwhich looked at the benefits and safety of adding topical ice therapy to medications commonly used for treating acute goutprednisolone and colchicineOver a one week periodin addition to prednisolone and colchicineice was applied to the skin overlying the joints affected by acute goutfor half-an-hourfour times per dayto relieve symptoms of pain and warmth and to reduce signs of redness and swelling.

Using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stressThereforebefore having surgery or emergency treatmentor if you get a serious illness/injurytell your doctor or dentist that you are using this medication or have used this medication within the past 12 monthsTell your doctor right away if you develop unusual/extreme tiredness or weight lossIf you will be using this medication for a long timecarry a warning card or medical ID bracelet that identifies your use of this medication.

Prednisolone may also be used for purposes not listed in this medication guide.

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the use of methylprednisolone tablets in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regimen.