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Anti-inflammatory drugs such as ibuprofen are given three times a day, some of the prescription agents, including celebrex are given twice or once a day.

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Ulcerative colitis patients taking Celebrex also seemed to fare better with disease severityWhen researchers examined biopsy specimensthey sawan increase in disease severity in the placebo patientsSandborn says.

Celecoxib exhibits dose-proportional increase in exposure after oral administration up to 200 mg twice daily and less than proportional increase at hgher dosesIt has extensive distribution and high protein bindingIt is primarily metabolized by CYP2C9 with a half-life of approximately 11 hours.

In vitro studies indicate that celecoxib is not an inhibitor of cytochrome P450 2C92C19 or 3A4.

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A randomizeddouble-blind study in 430 RA patients was conducted in which an endoscopic examination was performed at 6 monthsThe incidence of endoscopic ulcers in patients taking CELEBREX 200 mg twice daily was 4vs15for patients taking diclofenac SR 75 mg twice dailyHoweverCELEBREX was not statistically different than diclofenac for clinically relevant GI outcomes in the CLASS trialsee Clinical Studies

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they required a doctor s evaluation before they would authorize a return to celebrex.