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Phamacokintics: good absoption with pak concntation at 3 hous and a hal-li 17 hous. xctd unchangd in th uin by glomula iltation and tubula sction. ducd claanc in individuals > 60 yas and in patints with nal insuicincy: hal-li is incasd whn catinin claanc is lss than 40 ml/min. Amantadin is not movd by hamodialysis.

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Gastointstinal symptoms – mainly nausa but alsvomiting, diahoa, constipation, and loss apptit – a th majsid cts. In addition, amantadin has a wid ang toxicitis which may b in pat attibutabl tth anticholingic cts th dug, and som vsibl CNS sid cts may occu duing a 5-day-tatmnt in a substantial numb patints ( van Vois 1981 ). As th occunc advs cts is dos-latd, advs vnts a paticulaly common in th ldly and thos with impaid nal unction. Sid cts bgin within twdays th stat th dug, and usually disappa apidly at cssation tatmnt.

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